Embryonic stem (ES) cells are derived from the inner cell mass (ICM) of blastocysts. These cells are pluripotent as they exhibit the ability to differentiate into most of the specialized cell types. Epigenetic modifications are crucial to sustain the pluripotent state of ES cells while suppressing cell differentiation. Our long term goal is to define epigenetic mechanism for the maintenance of pluripotency in ES cells and early embryos. We will focus on dissecting functions of novel epigenetic factors with a combination of molecular, cellular and live imaging approaches.
Department of Biochemistry
Yong Loo Lin School of Medicine
National University of Singapore
8 Medical Drive, MD7 #02-07